Laser Therapy is being increasingly used in rehabilitation medicine for both veterinary and human patients. The term LASER stands for “Light Amplification by Stimulated Emission of Radiation.”
Laser Therapy works through light penetration into the patient’s tissues to positively influence cellular function and tissue repair. It does this through a photochemical process that excites the mitochondria within cells. The wavelength of the light governs the depth of tissue penetration with near-infrared light penetrating more deeply than ordinary red light. When the mitochondria are excited, this results in activation of a cellular signaling cascade utilizing ATP (adenosine triphosphate, the energy source for the cell), nitric oxide (NO), and reactive oxygen species (ROS). Laser therapy increases both cellular ATP production as well as cellular metabolism to help injured cells heal1. It stimulates growth factors such as fibroblastic growth factor 2, epithelial growth factor, and nerve growth factor2,1. Nitric oxide (NO) is a potent vasodilator, serving to relax endothelial cells within blood vessels to improve blood flow and improve healing2. The effect of light energy to increase local production and release of NO also helps with pain relief, and resolution of edema, as well as acting to improve lymphatic drainage to reduce swelling and to improve wound healing through the production of new blood vessels3. Furthermore, the activation of ROS can help with the synthesis of proteins that are important in tissue repair. They also help play a role in tissue oxygenation, and help modulate inflammatory mediators4. Importantly, ROS increases the metabolism, proliferation, migration, and synthesis of proteins that are used for tendon and wound healing2, 5. There is additional evidence that laser therapy has a protective role in the degradation of cartilage and synovitis in animals with progressive osteoarthritis6. Laser therapy has also been shown to reduce neuropathic pain and alter inflammatory events associated with peripheral nerve injury7. It can increase the threshold for pain fibers, increase endorphins, activate endogenous opioids, and attract opioids to injured sites, all of which are valuable in reducing the sensation of pain in patients with both acute and chronic injuries8.
In summary, laser therapy alters tissue physiology to:
• Promote cellular growth, proliferation, and repair
• Help with pain control through endorphin release
• Increase blood supply to injured tissues to assist healing
• Help muscles relax
• Reduce inflammation
• Speed-up recovery
Acute conditions often respond more quickly to laser therapy. Although chronic conditions can still be responsive, they tend to be more challenging and may require a lengthier period of treatment to achieve patient comfort. Therapy for chronic conditions typically begins with an induction period; usually a protocol of up to 3 times a week until a response is seen, then tapering to twice a week for several weeks, then once a week, before finally settling at a treatment frequency that keeps the patient comfortable.
1. Karu, T. (2010) Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP. Photomed Laser Surg. 28(2):159-160.
2. Hamblin, M.R. and Demidova, T.N. (2006) Mechanisms of low level light therapy. Proc of SPIE. 6140(612001):1-1
3. Hamblin, M.R. (2008) The role of nitric oxide in low level light therapy. Proc of SPIE. 6846(684602).
4. Chung, H. et al. (2012) The nits and bolts of low-level laser (light) therapy. Ann Biomed Eng. 40(2):516-533.
5. Peplow, P.V. et al, (2010) Laser photobiomodulation of proliferation of cells in culture: a review of human and animal studies. Photomed Laser Surg. 28(Suppl. 1):S3-S40.
6. Wang, et al, (2014). Effects of low-level laser therapy on joint pain, synovitis, anabolic, and catabolic factors in a progressive osteoarthritis rabbit model. Lasers Med Sci. Nov 29(6): 1875-85.
7. Hsieh, Y.L. et al. (2012) Low-level light therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constrictive injury: possible involvements in hypoxia-inducible factor 1alpha (HIF-1alpha). J Comp Neurol. 520913):2903-2916.
8. Cidral-Filho, F.J. et al. (2014) Light emitting diode therapy induces analgesia in a mouse model in postoperative pain through activation of peripheral opioid receptors and the L-arginine/nitric oxide pathway. Lasers Med Sci. 29(2):695-702.